Gabriele Holtappels Selected Research

Enterotoxins (Enterotoxin)

1/2017	IL-21 Is Increased in Nasal Polyposis and after Stimulation with Staphylococcus aureus Enterotoxin B.
1/2016	Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers.
8/2015	Is immunoglobulin E to Staphylococcus aureus enterotoxins associated with asthma at 20 years?
1/2014	Mixed T helper cell signatures in chronic rhinosinusitis with and without polyps.
8/2012	Specific IgE against Staphylococcus aureus enterotoxins: an independent risk factor for asthma.
11/2010	Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma.
9/2009	Detection of Staphylococcus aureus in nasal tissue with peptide nucleic acid-fluorescence in situ hybridization.
5/2008	Detection of enterotoxin DNA in Staphylococcus aureus strains obtained from the middle meatus in controls and nasal polyp patients.
1/2008	Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps.
4/2007	Staphylococcus aureus sensitization and allergic disease in early childhood: population-based birth cohort study.

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Gabriele Holtappels Research Topics

Disease

27	Nasal Polyps (Nasal Polyp) 01/2022 - 03/2004
26	Rhinosinusitis 01/2022 - 09/2003
21	Inflammation (Inflammations) 01/2022 - 11/2002
18	Asthma (Bronchial Asthma) 01/2021 - 05/2003
9	Polyps 01/2019 - 07/2006
3	Chronic Obstructive Pulmonary Disease (COPD) 10/2020 - 09/2004
3	Hypersensitivity (Allergy) 10/2020 - 04/2009
2	Allergic Rhinitis 06/2020 - 01/2012
2	Eosinophilia 01/2018 - 05/2013
2	Hyperplasia 01/2018 - 01/2013
2	Infections 01/2018 - 01/2016
2	Cystic Fibrosis (Mucoviscidosis) 01/2015 - 01/2014
2	Edema (Dropsy) 01/2013 - 09/2009
1	Dust Mite Allergy 06/2020
1	Rhinitis 06/2020
1	Atopic Dermatitis (Atopic Eczema) 01/2019
1	Bronchial Hyperreactivity 01/2018
1	Nose Diseases (Disease, Nose) 01/2015
1	Metaplasia 05/2013
1	Respiratory Hypersensitivity 05/2013
1	Chronic Disease (Chronic Diseases) 09/2009

Drug/Important Bio-Agent (IBA)

23	Immunoglobulin E (IgE)IBA 01/2022 - 11/2002
15	Enterotoxins (Enterotoxin)IBA 01/2017 - 11/2002
14	Interleukin-5 (Interleukin 5)IBA 01/2022 - 03/2004
14	CytokinesIBA 10/2020 - 01/2008
8	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2008
6	AntibodiesIBA 08/2012 - 03/2004
4	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2015
4	Interleukin-33IBA 01/2021 - 01/2018
4	Interleukin-13IBA 01/2019 - 01/2008
4	Eosinophil Cationic ProteinIBA 11/2010 - 07/2006
4	Transforming Growth Factor beta (TGF-beta)IBA 03/2010 - 05/2002
3	AllergensIBA 06/2020 - 08/2012
3	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2016 - 03/2004
3	CollagenIBA 01/2013 - 08/2009
3	SuperantigensIBA 08/2012 - 11/2002
3	Peroxidase (Myeloperoxidase)IBA 05/2010 - 07/2006
2	Interleukin-17 (Interleukin 17)IBA 01/2021 - 01/2016
2	InterleukinsIBA 10/2020 - 11/2002
2	Serine Proteases (Serine Protease)IBA 01/2020 - 01/2018
2	Messenger RNA (mRNA)IBA 01/2017 - 05/2010
2	GlucocorticoidsIBA 01/2015 - 05/2010
2	Interleukin-4 (Interleukin 4)IBA 01/2014 - 01/2008
2	SteroidsIBA 08/2012 - 05/2010
2	Biological ProductsIBA 05/2010 - 11/2006
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2022
1	Omalizumab (Xolair)FDA Link 01/2022
1	Interleukin-9 (Interleukin 9)IBA 10/2020
1	ChemokinesIBA 01/2019
1	Interleukin-4 Receptors (Interleukin 4 Receptor)IBA 01/2019
1	Chemokine CCL24IBA 01/2019
1	Chemokine CCL18IBA 01/2019
1	Monoclonal AntibodiesIBA 01/2019
1	Chemokine CCL26IBA 01/2019
1	dupilumabIBA 01/2019
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2018
1	Toll-Like Receptor 2IBA 01/2018
1	Peptide Hydrolases (Proteases)FDA Link 01/2018
1	interleukin-21 (interleukin 21)IBA 01/2017
1	S100 Proteins (S 100 Protein)IBA 01/2016
1	Blocking AntibodiesIBA 01/2016
1	Antiviral Agents (Antivirals)IBA 01/2016
1	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 01/2015
1	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 09/2014
1	Formaldehyde (Formol)FDA Link 09/2013
1	Immunoglobulins (Immunoglobulin)IBA 05/2013
1	SmokeIBA 05/2013
1	Cadherins (E-Cadherin)IBA 01/2013
1	Extracellular Matrix ProteinsIBA 01/2013
1	OccludinIBA 01/2013
1	Fibronectins (Fibronectin)IBA 01/2013
1	Adrenal Cortex Hormones (Corticosteroids)IBA 08/2012
1	Syk KinaseIBA 03/2011
1	Immunoglobulin G (IgG)IBA 01/2011
1	Methylprednisolone FDA LinkGeneric 05/2010
1	Anti-Bacterial Agents (Antibiotics)IBA 05/2010
1	LeptinIBA 05/2010
1	Doxycycline (Periostat)FDA LinkGeneric 05/2010
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 05/2010
1	Tissue Inhibitor of Metalloproteinase-3IBA 05/2010
1	Matrix Metalloproteinases (MMPs)IBA 05/2010
1	Tissue Inhibitor of Metalloproteinase-1IBA 05/2010
1	Tissue Inhibitor of Metalloproteinase-2IBA 05/2010
1	Complement System Proteins (Complement)IBA 09/2009
1	Complement Membrane Attack Complex (Membrane Attack Complex)IBA 09/2009
1	Protein Isoforms (Isoforms)IBA 08/2009
1	Histamine (Histamine Dihydrochloride)FDA Link 04/2009
1	ProstaglandinsIBA 04/2009
1	anti-IgE antibodiesIBA 04/2009
1	Prostaglandin D2IBA 04/2009
1	LeukotrienesIBA 04/2009
1	Tryptases (Tryptase)IBA 04/2009
1	Leukotriene C4IBA 04/2009
1	DNA (Deoxyribonucleic Acid)IBA 05/2008
1	Staphylococcal Protein A (Protein A)IBA 01/2008
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2008

Therapy/Procedure

3	Therapeutics 01/2014 - 09/2005
1	Precision Medicine 01/2021
1	Drug Therapy (Chemotherapy) 01/2012
1	Stents 11/2008